NAD+ drives cellular energy, DNA repair, and the activation of sirtuins, key proteins linked to longevity and skin resilience. NAD+ levels steadily decline as we age, and environmental stressors such as UV exposure, pollution, and chronic inflammation accelerate that depletion. Without sufficient NAD+, cells lose their ability to repair damage and maintain optimal function, resulting in visible signs of aging like dullness, loss of firmness, and wrinkles.

Effective Retinoids, including HPR, don’t just treat surface-level aging. They influence deep molecular processes, directly countering photo-damage (the single biggest cause of NAD+ loss in skin) by boosting cell turnover and collagen synthesis. This action reduces the excessive strain on NAD+ reserves caused by constant repair demands.

Further, retinoids activate sirtuin pathways, which depend on NAD+ for proper function. This activation supports mitochondrial health, skin barrier repair, and antioxidant responses, meaning retinoids help sustain NAD+ production from within, supporting cellular energy cycles and long-term skin vitality.

Hydroxypinacolone retinoate (HPR) is a next-generation retinoid ester that binds directly to retinoic acid receptors, skipping the multi-step metabolism required by traditional retinol and retinaldehyde. This allows HPR to deliver strong anti-aging effects, accelerating cell renewal, stimulating collagen production, and improving elasticity while causing much less irritation than prescription retinoids.

Because HPR is both highly effective and gentle, it fits seamlessly into a longevity regimen focused on cellular repair and barrier health, a direct intersection with NAD+ biology, minus the pitfalls of topical NAD+ itself.